Ontology highlight
ABSTRACT:
SUBMITTER: Penheiter AR
PROVIDER: S-EPMC4461733 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Penheiter Alan R AR Erdogan Sibel S Murphy Stephen J SJ Hart Steven N SN Felipe Lima Joema J Rakhshan Rohakhtar Fariborz F O'Brien Daniel R DR Bamlet William R WR Wuertz Ryan E RE Smyrk Thomas C TC Couch Fergus J FJ Vasmatzis George G Bender Claire E CE Carlson Stephanie K SK
BioMed research international 20150527
We used a target-centric strategy to identify transporter proteins upregulated in pancreatic ductal adenocarcinoma (PDAC) as potential targets for a functional imaging probe to complement existing anatomical imaging approaches. We performed transcriptomic profiling (microarray and RNASeq) on histologically confirmed primary PDAC tumors and normal pancreas tissue from 33 patients, including five patients whose tumors were not visible on computed tomography. Target expression was confirmed with im ...[more]