Ontology highlight
ABSTRACT:
SUBMITTER: Mardente S
PROVIDER: S-EPMC4461734 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Mardente S S Mari E E Massimi I I Fico F F Faggioni A A Pulcinelli F F Antonaci A A Zicari A A
BioMed research international 20150527
High mobility group box 1 (HMGB1) is an ubiquitous protein that plays different roles in the nucleus, cytoplasm, and extracellular space. It is an important DAMP molecule that allows communication between damaged or tumor cells and the immune system. Tumor cells exploit HMGB1's ability to activate intracellular pathways that lead to cell growth and migration. Papillary thyroid cancer is a well-differentiated tumor and is often used to study relationships between cells and the inflammatory microe ...[more]