Ontology highlight
ABSTRACT:
SUBMITTER: Cole A
PROVIDER: S-EPMC4461837 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Cole Alicia A Wang Zezhou Z Coyaud Etienne E Voisin Veronique V Gronda Marcela M Jitkova Yulia Y Mattson Rachel R Hurren Rose R Babovic Sonja S Maclean Neil N Restall Ian I Wang Xiaoming X Jeyaraju Danny V DV Sukhai Mahadeo A MA Prabha Swayam S Bashir Shaheena S Ramakrishnan Ashwin A Leung Elisa E Qia Yi Hua YH Zhang Nianxian N Combes Kevin R KR Ketela Troy T Lin Fengshu F Houry Walid A WA Aman Ahmed A Al-Awar Rima R Zheng Wei W Wienholds Erno E Xu Chang Jiang CJ Dick John J Wang Jean C Y JC Moffat Jason J Minden Mark D MD Eaves Connie J CJ Bader Gary D GD Hao Zhenyue Z Kornblau Steven M SM Raught Brian B Schimmer Aaron D AD
Cancer cell 20150601 6
From an shRNA screen, we identified ClpP as a member of the mitochondrial proteome whose knockdown reduced the viability of K562 leukemic cells. Expression of this mitochondrial protease that has structural similarity to the cytoplasmic proteosome is increased in leukemic cells from approximately half of all patients with AML. Genetic or chemical inhibition of ClpP killed cells from both human AML cell lines and primary samples in which the cells showed elevated ClpP expression but did not affec ...[more]