Ontology highlight
ABSTRACT:
SUBMITTER: Santiago AE
PROVIDER: S-EPMC4462183 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Santiago Araceli E AE Mann Barbara J BJ Qin Aiping A Cunningham Aimee L AL Cole Leah E LE Grassel Christen C Vogel Stefanie N SN Levine Myron M MM Barry Eileen M EM
Pathogens and disease 20150517 6
Francisella tularensis (Ft), the etiological agent of tularemia and a Tier 1 select agent, has been previously weaponized and remains a high priority for vaccine development. Ft tularensis (type A) and Ft holarctica (type B) cause most human disease. We selected six attenuating genes from the live vaccine strain (LVS; type B), F. novicida and other intracellular bacteria: FTT0507, FTT0584, FTT0742, FTT1019c (guaA), FTT1043 (mip) and FTT1317c (guaB) and created unmarked deletion mutants of each i ...[more]