Ontology highlight
ABSTRACT:
SUBMITTER: Willy JA
PROVIDER: S-EPMC4462938 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Willy Jeffrey A JA Young Sara K SK Stevens James L JL Masuoka Howard C HC Wek Ronald C RC
Molecular biology of the cell 20150422 12
Free fatty acid induction of inflammation and cell death is an important feature of nonalcoholic steatohepatitis (NASH) and has been associated with disruption of the endoplasmic reticulum and activation of the unfolded protein response (UPR). After chronic UPR activation, the transcription factor CHOP (GADD153/DDIT3) triggers cell death; however, the mechanisms linking the UPR or CHOP to hepatoceullular injury and inflammation in the pathogenesis of NASH are not well understood. Using HepG2 and ...[more]