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Thiazole formation through a modified Gewald reaction.

ABSTRACT: The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the substitution of the ?-carbon to the cyano group.

SUBMITTER: Mallia CJ

PROVIDER: S-EPMC4464301 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Thiazole formation through a modified Gewald reaction.

Mallia Carl J CJ Englert Lukas L Walter Gary C GC Baxendale Ian R IR

Beilstein journal of organic chemistry 20150526

The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the substitution of the α-carbon to the cyano group. ...[more]

PMID: 26124889

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