Ontology highlight
ABSTRACT:
SUBMITTER: Augustin MM
PROVIDER: S-EPMC4464957 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Augustin Megan M MM Ruzicka Dan R DR Shukla Ashutosh K AK Augustin Jörg M JM Starks Courtney M CM O'Neil-Johnson Mark M McKain Michael R MR Evans Bradley S BS Barrett Matt D MD Smithson Ann A Wong Gane Ka-Shu GK Deyholos Michael K MK Edger Patrick P PP Pires J Chris JC Leebens-Mack James H JH Mann David A DA Kutchan Toni M TM
The Plant journal : for cell and molecular biology 20150601 6
Steroid alkaloids have been shown to elicit a wide range of pharmacological effects that include anticancer and antifungal activities. Understanding the biosynthesis of these molecules is essential to bioengineering for sustainable production. Herein, we investigate the biosynthetic pathway to cyclopamine, a steroid alkaloid that shows promising antineoplastic activities. Supply of cyclopamine is limited, as the current source is solely derived from wild collection of the plant Veratrum californ ...[more]