Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer.

ABSTRACT: Despite considerable progress being made in understanding pancreatic cancer (PC) pathogenesis, it still remains the 10th most often diagnosed malignancy in the world and 4th leading cause of cancer related deaths in the United States with a five year survival rate of only 6%. The aggressive nature, lack of early diagnostic and prognostic markers, late clinical presentation, and limited efficacy of existing treatment regimens make PC a lethal cancer with high mortality and poor prognosis. Therefore, novel reliable biomarkers and molecular targets are urgently needed to combat this deadly disease. MicroRNAs (miRNAs) are short (19-24 nucleotides) non-coding RNA molecules implicated in the regulation of gene expression at post-transcriptional level and play significant roles in various physiol

SUBMITTER: Rachagani S 

PROVIDER: S-EPMC4465296 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature