P53 Represses the Oncogenic Sno-MiR-28 Derived from a SnoRNA.
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ABSTRACT:
SUBMITTER: Yu F
PROVIDER: S-EPMC4465335 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
p53 Represses the Oncogenic Sno-MiR-28 Derived from a SnoRNA.
Yu Feng F Bracken Cameron P CP Pillman Katherine A KA Lawrence David M DM Goodall Gregory J GJ Callen David F DF Neilsen Paul M PM
PloS one 20150610 6
p53 is a master tumour repressor that participates in vast regulatory networks, including feedback loops involving microRNAs (miRNAs) that regulate p53 and that themselves are direct p53 transcriptional targets. We show here that a group of polycistronic miRNA-like non-coding RNAs derived from small nucleolar RNAs (sno-miRNAs) are transcriptionally repressed by p53 through their host gene, SNHG1. The most abundant of these, sno-miR-28, directly targets the p53-stabilizing gene, TAF9B. Collective ...[more]
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