Ontology highlight
ABSTRACT:
SUBMITTER: Egan ES
PROVIDER: S-EPMC4465434 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Egan Elizabeth S ES Jiang Rays H Y RH Moechtar Mischka A MA Barteneva Natasha S NS Weekes Michael P MP Nobre Luis V LV Gygi Steven P SP Paulo Joao A JA Frantzreb Charles C Tani Yoshihiko Y Takahashi Junko J Watanabe Seishi S Goldberg Jonathan J Paul Aditya S AS Brugnara Carlo C Root David E DE Wiegand Roger C RC Doench John G JG Duraisingh Manoj T MT
Science (New York, N.Y.) 20150501 6235
Efforts to identify host determinants for malaria have been hindered by the absence of a nucleus in erythrocytes, which precludes genetic manipulation in the cell in which the parasite replicates. We used cultured red blood cells derived from hematopoietic stem cells to carry out a forward genetic screen for Plasmodium falciparum host determinants. We found that CD55 is an essential host factor for P. falciparum invasion. CD55-null erythrocytes were refractory to invasion by all isolates of P. f ...[more]