Ontology highlight
ABSTRACT:
SUBMITTER: Gay DL
PROVIDER: S-EPMC4465595 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Gay Denise L DL Yang Chao-Chun CC Plikus Maksim V MV Ito Mayumi M Rivera Charlotte C Treffeisen Elsa E Doherty Laura L Spata Michelle M Millar Sarah E SE Cotsarelis George G
The Journal of investigative dermatology 20140710 1
Genetic studies suggest that the major events of human hair follicle development are similar to those in mice, but detailed analyses of this process are lacking. In mice, hair follicle placode "budding" is initiated by invagination of Wnt-induced epithelium into the underlying mesenchyme. Modification of adherens junctions (AJs) is clearly required for budding. Snail-mediated downregulation of AJ component E-cadherin is important for placode budding in mice. Beta-catenin, another AJ component, h ...[more]