Dataset Information

Early Childhood Father Absence and Depressive Symptoms in Adolescent Girls from a UK Cohort: The Mediating Role of Early Menarche.

ABSTRACT: Absence of the biological father in early childhood has been linked to depressive symptoms in mid-adolescent girls. Earlier studies have linked father absence to early timing of menarche, and early menarche is a risk factor for increased depressive symptoms in adolescence. No studies, however, have examined whether the association between father absence and depressive symptoms may be explained by the early onset of menarche. This study investigated whether age at menarche mediates the association between father absence in early childhood (birth to 5 years) and depressive symptoms in adolescent girls aged 14 years. The study sample comprised 7056 girls from a large UK birth cohort (Avon Longitudinal Study of Parents and Children) who provided data on age at onset of menarche and depressive symptoms assessed using the Short Mood and Feelings Questionnaire at 14 years. Mothers provided data on father absence from the birth of the study child up to 10 years. Using structural equation modelling, we found that 15 % of the total estimated association between father absence in early childhood and depressive symptoms at 14 years was explained by early age at menarche. In addition to the mediated effect, father absence was linked to an 11 % increase in depressive symptoms in adolescence. The findings suggest that early age at menarche is one of the pathways linking early childhood father absence and depressive symptoms in mid-adolescent girls. Preventive strategies could be targeting young girls at risk for depressive symptoms as a function of stressful family factors (e.g., biological father absence) and earlier menarche.

SUBMITTER: Culpin I

PROVIDER: S-EPMC4465664 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Similar Datasets

Project description:UNLABELLED:Puberty is an important developmental stage wherein hormonal shifts mediate the physical and physiological changes that lead to menarche, but until now, the bacterial composition of vaginal microbiota during this period has been poorly characterized. We performed a prospective longitudinal study of perimenarcheal girls to gain insight into the timing and sequence of changes that occur in the vaginal and vulvar microbiota during puberty. The study enrolled 31 healthy, premenarcheal girls between the ages of 10 and 12 years and collected vaginal and vulvar swabs quarterly for up to 3 years. Bacterial composition was characterized by Roche 454 pyrosequencing and classification of regions V1 to V3 of 16S rRNA genes. Contrary to expectations, lactic acid bacteria, primarily Lactobacillus spp., were dominant in the microbiota of most girls well before the onset of menarche in the early to middle stages of puberty. Gardnerella vaginalis was detected at appreciable levels in approximately one-third of subjects, a notable finding considering that this organism is commonly associated with bacterial vaginosis in adults. Vulvar microbiota closely resembled vaginal microbiota but often exhibited additional taxa typically associated with skin microbiota. Our findings suggest that the vaginal microbiota of girls begin to resemble those of adults well before the onset of menarche. IMPORTANCE:This study addresses longitudinal changes in vaginal and vulvar microbial communities prior to and immediately following menarche. The research is significant because microbial ecology of the vagina is an integral aspect of health, including resistance to infections. The physiologic changes of puberty and initiation of cyclic menstruation are likely to have profound effects on vaginal microbiota, but almost nothing is known about changes that normally occur during this time. Our understanding has been especially hampered by the lack of thorough characterization of microbial communities using techniques that do not rely on the cultivation of fastidious bacteria, as well as a dearth of studies on girls in the early to middle stages of puberty. This study improves our understanding of the normal development of vaginal microbiota during puberty and onset of menarche and may better inform clinical approaches to vulvovaginal care of adolescent girls.

Dataset Information

Early Childhood Father Absence and Depressive Symptoms in Adolescent Girls from a UK Cohort: The Mediating Role of Early Menarche.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets