Ontology highlight
ABSTRACT:
SUBMITTER: Kruyer A
PROVIDER: S-EPMC4465852 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Kruyer Anna A Soplop Nadine N Strickland Sidney S Norris Erin H EH
Hypertension (Dallas, Tex. : 1979) 20150504 1
Numerous epidemiological studies link vascular disorders, such as hypertension, diabetes mellitus, and stroke, with Alzheimer's disease (AD). Hypertension, specifically, is an important modifiable risk factor for late-onset AD. To examine the link between midlife hypertension and the onset of AD later in life, we chemically induced chronic hypertension in the TgSwDI mouse model of AD in early adulthood. Hypertension accelerated cognitive deficits in the Barnes maze test (P<0.05 after 3 months of ...[more]