Ontology highlight
ABSTRACT:
SUBMITTER: Repetto-Llamazares AH
PROVIDER: S-EPMC4466226 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Repetto-Llamazares Ada H V AH Larsen Roy H RH Patzke Sebastian S Fleten Karianne G KG Didierlaurent David D Pichard Alexandre A Pouget Jean Pierre JP Dahle Jostein J
PloS one 20150611 6
177Lu-DOTA-HH1 (177Lu-HH1) is a novel anti-CD37 radioimmunoconjugate developed to treat non-Hodgkin lymphoma. Mice with subcutaneous Ramos xenografts were treated with different activities of 177Lu-HH1, 177Lu-DOTA-rituximab (177Lu-rituximab) and non-specific 177Lu-DOTA-IgG1 (177Lu-IgG1) and therapeutic effect and toxicity of the treatment were monitored. Significant tumor growth delay and increased survival of mice were observed in mice treated with 530 MBq/kg 177Lu-HH1 as compared with mice tre ...[more]