Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC4466433 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Li Deng D Wang Peng P Li Yuxi Y Xie Zhongyu Z Wang Le L Su Hongjun H Deng Wen W Wu Yanfeng Y Shen Huiyong H
Stem cells international 20150601
Previous studies have demonstrated the immunosuppressive effects of both all-trans retinoic acid (ATRA) and mesenchymal stem cells (MSCs). The present study aimed to assess the immunoregulatory effects of ATRA on MSCs in the treatment of ankylosing spondylitis (AS). Bone marrow-derived MSCs from healthy donors were pretreated with ATRA and cocultured with CD3/28-activated peripheral blood mononuclear cells (PBMCs) derived from AS patients. Frequencies of Th17 and regulatory T (Treg) cells were a ...[more]