Ontology highlight
ABSTRACT:
SUBMITTER: Fischer U
PROVIDER: S-EPMC4466667 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Fischer Ulrike U Backes Christina C Raslan Abdulrahman A Keller Andreas A Meier Carola C Meese Eckart E
Oncotarget 20150301 9
In development of amphibians and flies, gene amplification is one of mechanisms to increase gene expression. In mammalian cells, gene amplification seems to be restricted to tumorigenesis and acquiring of drug-resistance in cancer cells. Here, we report a complex gene amplification pattern in mouse neural progenitor cells during differentiation with approximately 10% of the genome involved. Half of the amplified mouse chromosome regions overlap with amplified regions previously reported in human ...[more]