Ontology highlight
ABSTRACT:
SUBMITTER: Le AP
PROVIDER: S-EPMC4466685 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Le Audrey P AP Huang Yong Y Pingle Sandeep C SC Kesari Santosh S Wang Huaien H Yong Raymund L RL Zou Hongyan H Friedel Roland H RH
Oncotarget 20150301 9
Invasive growth is a major determinant of the high lethality of malignant gliomas. Plexin-B2, an axon guidance receptor important for mediating neural progenitor cell migration during development, is upregulated in gliomas, but its function therein remains poorly understood. Combining bioinformatic analyses, immunoblotting and immunohistochemistry of patient samples, we demonstrate that Plexin-B2 is consistently upregulated in all types of human gliomas and that its expression levels correlate w ...[more]