Ontology highlight
ABSTRACT:
SUBMITTER: Salah Z
PROVIDER: S-EPMC4467124 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Salah Zaidoun Z Arafeh Rand R Maximov Vadim V Galasso Marco M Khawaled Saleh S Abou-Sharieha Samah S Volinia Stefano S Jones Kevin B KB Croce Carlo M CM Aqeilan Rami I RI
Oncotarget 20150301 7
Osteosarcoma (OS) is the most common primary malignant bone tumor in adolescents and young adults. The essential mechanisms underlying osteosarcomagenesis and progression continue to be obscure. MicroRNAs (miRNAs) have far-reaching effects on the cellular biology of development and cancer. We recently reported that unique miRNA signatures associate with the pathogenesis and progression of OS. Of particular interest, we found that higher expression of miR-27a is associated with clinical metastati ...[more]