Ontology highlight
ABSTRACT:
SUBMITTER: Huang HL
PROVIDER: S-EPMC4467128 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Huang Han-Li HL Peng Chieh-Yu CY Lai Mei-Jung MJ Chen Chun-Han CH Lee Hsueh-Yun HY Wang Jing-Chi JC Liou Jing-Ping JP Pan Shiow-Lin SL Teng Che-Ming CM
Oncotarget 20150301 7
Histone deacetylase (HDAC) inhibitor has been a promising therapeutic option in cancer therapy due to its ability to induce growth arrest, differentiation, and apoptosis. In this study, we demonstrated that MPT0E028, a novel HDAC inhibitor, reduces the viability of B-cell lymphomas by inducing apoptosis and shows a more potent HDAC inhibitory effect compared to SAHA, the first HDAC inhibitor approved by the FDA. In addition to HDACs inhibition, MPT0E028 also possesses potent direct Akt targeting ...[more]