Ontology highlight
ABSTRACT:
SUBMITTER: Tripathi K
PROVIDER: S-EPMC4467145 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Tripathi Kaushlendra K Hussein Usama K UK Anupalli Roja R Barnett Reagan R Bachaboina Lavanya L Scalici Jennifer J Rocconi Rodney P RP Owen Laurie B LB Piazza Gary A GA Palle Komaraiah K
Oncotarget 20150301 7
Allyl isothiocyanate (AITC), a constituent of many cruciferous vegetables exhibits significant anticancer activities in many cancer models. Our studies provide novel insights into AITC-induced anticancer mechanisms in human A549 and H1299 non-small cell lung cancer (NSCLC) cells. AITC exposure induced replication stress in NSCLC cells as evidenced by γH2AX and FANCD2 foci, ATM/ATR-mediated checkpoint responses and S and G2/M cell cycle arrest. Furthermore, AITC-induced FANCD2 foci displayed co-l ...[more]