Ontology highlight
ABSTRACT:
SUBMITTER: Huang MJ
PROVIDER: S-EPMC4467392 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Huang Miao-Juei MJ Hu Rey-Heng RH Chou Chih-Hsing CH Hsu Chia-Lang CL Liu Ya-Wen YW Huang John J Hung Ji-Shiang JS Lai I-Rue IR Juan Hsueh-Fen HF Yu Sung-Liang SL Wu Yao-Ming YM Huang Min-Chuan MC
Oncotarget 20150301 8
O-glycosylation is a common protein modification. Aberrant O-glycosylation is associated with many cancers. GALNT1 is a GalNAc-transferase that initiates protein O-glycosylation. We found that GALNT1 is frequently up-regulated in hepatocellular carcinoma (HCC) and is associated with poor patient survival. Overexpression of GALNT1 increased and knockdown decreased HCC cell migration and invasion. Knockdown of GALNT1 inhibited EGF-induced migration and invasion. Knockdown of GALNT1 decreased EGFR ...[more]