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Clinicopathologic and outcome features of superficial high-grade and deep low-grade squamous cell carcinomas of the penis.

ABSTRACT: PURPOSE:To report the clinicopathologic and outcome features of superficial high-grade and deep low-grade penile squamous cell carcinomas. METHODS:From a retrospectively-collected series of patients with penile cancer we identified 41 cases corresponding to 12 superficial high-grade tumors and 29 deep low-grade tumors. As outcomes we evaluated inguinal lymph node status, presence of tumor relapse, final nodal status, and cancer-specific death. Follow-up ranged from 0.8 to 386.7 months (mean 152.5 months, median 157.3 months). RESULTS:Clinicopathologic features were similar between superficial high-grade and deep low-grade tumors, except for a tendency (Fisher's exact [Formula: see text]) of the former to include tumors with a verruciform pattern of growth. A significantly higher proportion of inguinal lymph node metastasis was found in superficial high-grade tumors compared to deep low-grade tumors [4/5 (80%) vs. 1/5 (20%) respectively, Fisher's exact [Formula: see text]]. No significant differences were found regarding tumor relapse (Fisher's exact [Formula: see text]), final nodal status (Mantel-Cox's [Formula: see text]), or cancer-related death (Mantel-Cox's [Formula: see text]). CONCLUSIONS:Patients with superficial high-grade tumors had a significantly higher proportion of inguinal lymph node metastasis compared to patients with deep low-grade tumors. On this regard, prophylactic inguinal lymphadenectomy might be indicated in cases of superficial tumors with high-grade histology while in deeply invasive low-grade penile carcinomas a more conservative approach may be considered.

SUBMITTER: Chaux A

PROVIDER: S-EPMC4467594 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Clinicopathologic and outcome features of superficial high-grade and deep low-grade squamous cell carcinomas of the penis.

Chaux Alcides A

SpringerPlus 20150609

<h4>Purpose</h4>To report the clinicopathologic and outcome features of superficial high-grade and deep low-grade penile squamous cell carcinomas.<h4>Methods</h4>From a retrospectively-collected series of patients with penile cancer we identified 41 cases corresponding to 12 superficial high-grade tumors and 29 deep low-grade tumors. As outcomes we evaluated inguinal lymph node status, presence of tumor relapse, final nodal status, and cancer-specific death. Follow-up ranged from 0.8 to 386.7 mo ...[more]

PMID: 26090299

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Dataset Information

Clinicopathologic and outcome features of superficial high-grade and deep low-grade squamous cell carcinomas of the penis.

Publications

Clinicopathologic and outcome features of superficial high-grade and deep low-grade squamous cell carcinomas of the penis.

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