Ontology highlight
ABSTRACT:
SUBMITTER: Stukova M
PROVIDER: S-EPMC4467998 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Stukova Marina M Hall Matthew D MD Tsotsoros Samantha D SD Madigan James P JP Farrell Nicholas P NP Gottesman Michael M MM
Journal of inorganic biochemistry 20150514
The resistance of ovarian cancer towards front-line chemotherapy, usually cisplatin or carboplatin in combination with paclitaxel or docetaxel, remains a major clinical challenge. Resistance to these agents has been largely studied using cell lines selected for resistance to agents in vitro. We examined a series of paired cell lines derived from patients with ovarian cancer prior to chemotherapy (PEO1, PEO4, PEO14 and PEA1), and following the acquisition of resistance to a platinum-based chemoth ...[more]