Ontology highlight
ABSTRACT:
SUBMITTER: Adland E
PROVIDER: S-EPMC4468173 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Adland Emily E Paioni Paolo P Thobakgale Christina C Laker Leana L Mori Luisa L Muenchhoff Maximilian M Csala Anna A Clapson Margaret M Flynn Jacquie J Novelli Vas V Hurst Jacob J Naidoo Vanessa V Shapiro Roger R Huang Kuan-Hsiang Gary KH Frater John J Prendergast Andrew A Prado Julia G JG Ndung'u Thumbi T Walker Bruce D BD Carrington Mary M Jooste Pieter P Goulder Philip J R PJ
PLoS pathogens 20150615 6
HLA class I polymorphism has a major influence on adult HIV disease progression. An important mechanism mediating this effect is the impact on viral replicative capacity (VRC) of the escape mutations selected in response to HLA-restricted CD8+ T-cell responses. Factors that contribute to slow progression in pediatric HIV infection are less well understood. We here investigate the relationship between VRC and disease progression in pediatric infection, and the effect of HLA on VRC and on disease ...[more]