Ontology highlight
ABSTRACT:
SUBMITTER: Jeay S
PROVIDER: S-EPMC4468608 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Jeay Sébastien S Gaulis Swann S Ferretti Stéphane S Bitter Hans H Ito Moriko M Valat Thérèse T Murakami Masato M Ruetz Stephan S Guthy Daniel A DA Rynn Caroline C Jensen Michael R MR Wiesmann Marion M Kallen Joerg J Furet Pascal P Gessier François F Holzer Philipp P Masuya Keiichi K Würthner Jens J Halilovic Ensar E Hofmann Francesco F Sellers William R WR Graus Porta Diana D
eLife 20150512
Biomarkers for patient selection are essential for the successful and rapid development of emerging targeted anti-cancer therapeutics. In this study, we report the discovery of a novel patient selection strategy for the p53-HDM2 inhibitor NVP-CGM097, currently under evaluation in clinical trials. By intersecting high-throughput cell line sensitivity data with genomic data, we have identified a gene expression signature consisting of 13 up-regulated genes that predicts for sensitivity to NVP-CGM0 ...[more]