Ontology highlight
ABSTRACT:
SUBMITTER: Rozov A
PROVIDER: S-EPMC4468848 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Rozov Alexey A Demeshkina Natalia N Westhof Eric E Yusupov Marat M Yusupova Gulnara G
Nature communications 20150603
The decoding of mRNA on the ribosome is the least accurate process during genetic information transfer. Here we propose a unified decoding mechanism based on 11 high-resolution X-ray structures of the 70S ribosome that explains the occurrence of missense errors during translation. We determined ribosome structures in rare states where incorrect tRNAs were incorporated into the peptidyl-tRNA-binding site. These structures show that in the codon-anticodon duplex, a G·U mismatch adopts the Watson-C ...[more]