Ontology highlight
ABSTRACT:
SUBMITTER: Chapple CE
PROVIDER: S-EPMC4468855 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Chapple Charles E CE Robisson Benoit B Spinelli Lionel L Guien Céline C Becker Emmanuelle E Brun Christine C
Nature communications 20150609
Moonlighting proteins are a subclass of multifunctional proteins whose functions are unrelated. Although they may play important roles in cells, there has been no large-scale method to identify them, nor any effort to characterize them as a group. Here, we propose the first method for the identification of 'extreme multifunctional' proteins from an interactome as a first step to characterize moonlighting proteins. By combining network topological information with protein annotations, we identify ...[more]