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Extreme multifunctional proteins identified from a human protein interaction network.


ABSTRACT: Moonlighting proteins are a subclass of multifunctional proteins whose functions are unrelated. Although they may play important roles in cells, there has been no large-scale method to identify them, nor any effort to characterize them as a group. Here, we propose the first method for the identification of 'extreme multifunctional' proteins from an interactome as a first step to characterize moonlighting proteins. By combining network topological information with protein annotations, we identify 430 extreme multifunctional proteins (3% of the human interactome). We show that the candidates form a distinct sub-group of proteins, characterized by specific features, which form a signature of extreme multifunctionality. Overall, extreme multifunctional proteins are enriched in linear motifs and less intrinsically disordered than network hubs. We also provide MoonDB, a database containing information on all the candidates identified in the analysis and a set of manually curated human moonlighting proteins.

SUBMITTER: Chapple CE 

PROVIDER: S-EPMC4468855 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Extreme multifunctional proteins identified from a human protein interaction network.

Chapple Charles E CE   Robisson Benoit B   Spinelli Lionel L   Guien Céline C   Becker Emmanuelle E   Brun Christine C  

Nature communications 20150609


Moonlighting proteins are a subclass of multifunctional proteins whose functions are unrelated. Although they may play important roles in cells, there has been no large-scale method to identify them, nor any effort to characterize them as a group. Here, we propose the first method for the identification of 'extreme multifunctional' proteins from an interactome as a first step to characterize moonlighting proteins. By combining network topological information with protein annotations, we identify  ...[more]

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