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Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets.

ABSTRACT: Long noncoding RNAs are emerging as key players in various fundamental biological processes. We highlight the varied molecular mechanisms by which lncRNAs modulate gene expression in diverse cellular contexts and their role in early mammalian development in this review. Furthermore, it is being increasingly recognized that altered expression of lncRNAs is specifically associated with tumorigenesis, tumor progression and metastasis. We discuss various lncRNAs implicated in different cancer types with a focus on their clinical applications as potential biomarkers and therapeutic targets in the pathology of diverse cancers.

SUBMITTER: Fatima R

PROVIDER: S-EPMC4469312 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets.

Fatima Roshan R Akhade Vijay Suresh VS Pal Debosree D Rao Satyanarayana Mr SM

Molecular and cellular therapies 20150612

Long noncoding RNAs are emerging as key players in various fundamental biological processes. We highlight the varied molecular mechanisms by which lncRNAs modulate gene expression in diverse cellular contexts and their role in early mammalian development in this review. Furthermore, it is being increasingly recognized that altered expression of lncRNAs is specifically associated with tumorigenesis, tumor progression and metastasis. We discuss various lncRNAs implicated in different cancer types ...[more]

PMID: 26082843

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