A Limited Role for the Cell Cycle Regulator Cyclin A1 in Murine Leukemogenesis.
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ABSTRACT:
SUBMITTER: Baumer N
PROVIDER: S-EPMC4469679 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
A Limited Role for the Cell Cycle Regulator Cyclin A1 in Murine Leukemogenesis.
Bäumer Nicole N Bäumer Sebastian S Haak Miriam M Koschmieder Steffen S Schönig Kai K Berdel Wolfgang E WE Müller-Tidow Carsten C
PloS one 20150616 6
The quest for novel therapeutic targets in acute myeloid leukemia (AML) is still ongoing. One of such targets, cyclin A1, was shown to be overexpressed in AML including AML stem cells. However, the function of cyclin A1 in AML is largely unknown, and the data on its impact on patients' survival remain controversial. Therefore, we developed a transgenic mouse model of stem cell-directed inducible cyclin A1 overexpression and crossed these mice with PML-RARα-knockin mice, which develop an AML M3-l ...[more]
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