Safety and Efficacy Data on Vaccines and Immunization to Human Papillomavirus.
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SUBMITTER: Kash N
PROVIDER: S-EPMC4470159 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Safety and Efficacy Data on Vaccines and Immunization to Human Papillomavirus.
Kash Natalie N Lee Michael A MA Kollipara Ramya R Downing Christopher C Guidry Jacqueline J Tyring Stephen K SK
Journal of clinical medicine 20150403 4
Since the discovery of the causal association between human papillomavirus (HPV) and cervical cancer, efforts to develop an effective prophylactic vaccine to prevent high-risk HPV infections have been at the forefront of modern medical research. HPV causes 530,000 cervical cancer cases worldwide, which is the second most common cause of cancer deaths in women; a worldwide collaboration among epidemiologists, molecular biologists, vaccinologists, virologists, and clinicians helped lead to the dev ...[more]
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Project description:Human papillomavirus (HPV) vaccines are among the most effective vaccines available, the first to prevent infection by a mucosatropic sexually transmitted infectious agent and to do so without specific induction of mucosal immunity. Currently available prophylactic HPV vaccines are based on virus-like particles that self-assemble spontaneously from the L1 major capsid protein. The first HPV vaccine was licensed in 2006. All vaccines target HPV-16 and HPV-18, types which cause the majority of HPV-attributable cancers. As of 2020, HPV vaccines had been introduced into national immunization programs in more than 100 countries. Vaccination polices have evolved; most programs target vaccination of young adolescent girls, with an increasing number also including boys. The efficacy and safety found in prelicensure trials have been confirmed by data from national immunization programs. The dramatic impact and effectiveness observed has stimulated interest in ambitious disease reduction goals.
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