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Multiple independent autonomous hydraulic oscillators driven by a common gravity head.


ABSTRACT: Self-switching microfluidic circuits that are able to perform biochemical experiments in a parallel and autonomous manner, similar to instruction-embedded electronics, are rarely implemented. Here, we present design principles and demonstrations for gravity-driven, integrated, microfluidic pulsatile flow circuits. With a common gravity head as the only driving force, these fluidic oscillator arrays realize a wide range of periods (0.4?s-2?h) and flow rates (0.10-63??l?min(-1)) with completely independent timing between the multiple oscillator sub-circuits connected in parallel. As a model application, we perform systematic, parallel analysis of endothelial cell elongation response to different fluidic shearing patterns generated by the autonomous microfluidic pulsed flow generation system.

SUBMITTER: Kim SJ 

PROVIDER: S-EPMC4470298 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Multiple independent autonomous hydraulic oscillators driven by a common gravity head.

Kim Sung-Jin SJ   Yokokawa Ryuji R   Lesher-Perez Sasha Cai SC   Takayama Shuichi S  

Nature communications 20150615


Self-switching microfluidic circuits that are able to perform biochemical experiments in a parallel and autonomous manner, similar to instruction-embedded electronics, are rarely implemented. Here, we present design principles and demonstrations for gravity-driven, integrated, microfluidic pulsatile flow circuits. With a common gravity head as the only driving force, these fluidic oscillator arrays realize a wide range of periods (0.4 s-2 h) and flow rates (0.10-63 μl min(-1)) with completely in  ...[more]

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