Ontology highlight
ABSTRACT:
SUBMITTER: Pontiggia F
PROVIDER: S-EPMC4470301 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Pontiggia F F Pachov D V DV Clarkson M W MW Villali J J Hagan M F MF Pande V S VS Kern D D
Nature communications 20150615
The interconversion between inactive and active protein states, traditionally described by two static structures, is at the heart of signalling. However, how folded states interconvert is largely unknown due to the inability to experimentally observe transition pathways. Here we explore the free energy landscape of the bacterial response regulator NtrC by combining computation and nuclear magnetic resonance, and discover unexpected features underlying efficient signalling. We find that functiona ...[more]