Ontology highlight
ABSTRACT:
SUBMITTER: Chan LW
PROVIDER: S-EPMC4470483 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Chan Leslie W LW Wang Xu X Wei Hua H Pozzo Lilo D LD White Nathan J NJ Pun Suzie H SH
Science translational medicine 20150301 277
Clotting factor replacement is the standard management of acute bleeding in congenital and acquired bleeding disorders. We present a synthetic approach to hemostasis using an engineered hemostatic polymer (PolySTAT) that circulates innocuously in the blood, identifies sites of vascular injury, and promotes clot formation to stop bleeding. PolySTAT induces hemostasis by cross-linking the fibrin matrix within clots, mimicking the function of the transglutaminase factor XIII. Furthermore, synthetic ...[more]