Ontology highlight
ABSTRACT:
SUBMITTER: Gainor JF
PROVIDER: S-EPMC4470734 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Gainor Justin F JF Tan Daniel S W DS De Pas Tomasso T Solomon Benjamin J BJ Ahmad Aziah A Lazzari Chiara C de Marinis Filippo F Spitaleri Gianluca G Schultz Katherine K Friboulet Luc L Yeap Beow Y BY Engelman Jeffrey A JA Shaw Alice T AT
Clinical cancer research : an official journal of the American Association for Cancer Research 20150227 12
<h4>Purpose</h4>Anaplastic lymphoma kinase (ALK) rearrangements are important therapeutic targets in non-small cell lung cancer (NSCLC) that confer sensitivity to the ALK inhibitors crizotinib and ceritinib. To determine the outcome of sequential treatment with crizotinb and ceritinib, we retrospectively evaluated a cohort of ALK-positive patients treated with both agents.<h4>Experimental design</h4>We identified 73 ALK-positive NSCLC patients treated with crizotinib followed by ceritinib at fou ...[more]