Ontology highlight
ABSTRACT:
SUBMITTER: Boone BA
PROVIDER: S-EPMC4470814 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Boone B A BA Orlichenko L L Schapiro N E NE Loughran P P Gianfrate G C GC Ellis J T JT Singhi A D AD Kang R R Tang D D Lotze M T MT Zeh H J HJ
Cancer gene therapy 20150424 6
Neutrophil extracellular traps (NETs) are formed when neutrophils expel their DNA, histones and intracellular proteins into the extracellular space or circulation. NET formation is dependent on autophagy and is mediated by citrullination of histones to allow for the unwinding and subsequent expulsion of DNA. NETs have an important role in the pathogenesis of several sterile inflammatory diseases, including malignancy, therefore we investigated the role of NETs in the setting of pancreatic ductal ...[more]