Ontology highlight
ABSTRACT:
SUBMITTER: Sandgren KJ
PROVIDER: S-EPMC4471340 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Sandgren Kerrie J KJ Smed-Sörensen Anna A Forsell Mattias N MN Soldemo Martina M Adams William C WC Liang Frank F Perbeck Leif L Koup Richard A RA Wyatt Richard T RT Karlsson Hedestam Gunilla B GB Loré Karin K
Journal of immunology (Baltimore, Md. : 1950) 20130531 1
Advances in HIV-1 vaccine clinical trials and preclinical research indicate that the virus envelope glycoproteins (Env) are likely to be an essential component of a prophylactic vaccine. Efficient Ag uptake and presentation by dendritic cells (DCs) is important for strong CD4(+) Th cell responses and the development of effective humoral immune responses. In this study, we examined the capacity of distinct primary human DC subsets to internalize and present recombinant Env to CD4(+) T cells. Cons ...[more]