Unknown

Dataset Information

0

ADIPOQ polymorphism rs182052 is associated with clear cell renal cell carcinoma.


ABSTRACT: Recent studies have indicated that low circulating adiponectin concentrations are associated with a higher risk of several cancers, including renal cell carcinoma. In this case-control study, we examined the frequency of single nucleotide polymorphisms (rs182052G>A, rs266729C>G, and rs3774262G>A) in the adiponectin gene (ADIPOQ) in 1004 patients with clear cell renal cell carcinoma (ccRCC) compared with a group of healthy subjects (n = 1108). Fasting serum adiponectin concentrations were also examined. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95% CI). The association of serum adiponectin concentration with genetic variants was calculated using a multivariate linear regression model. A significantly higher ccRCC risk was associated with the rs182052 variant A allele (adjusted OR, 1.36 and 95% CI, 1.07-1.74 for AA vs GG, P = 0.013; adjusted OR, 1.27 and 95% CI, 1.04-1.56 for AA vs GG+AG, P = 0.019), and this positive association was more evident in overweight subjects. Fasting serum adiponectin was lower in subjects carrying A alleles of rs182052 in both ccRCC patients (? = -0.399, P = 0.018) and healthy controls (? = -0.371, P = 0.024). These results suggest that ADIPOQ rs182052 is significantly associated with ccRCC risk.

SUBMITTER: Zhang G 

PROVIDER: S-EPMC4471788 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

ADIPOQ polymorphism rs182052 is associated with clear cell renal cell carcinoma.

Zhang Guiming G   Gu Chengyuan C   Zhu Yao Y   Luo Lei L   Dong Dahai D   Wan Fangning F   Zhang Hailiang H   Shi Guohai G   Sun Lijiang L   Ye Dingwei D  

Cancer science 20150424 6


Recent studies have indicated that low circulating adiponectin concentrations are associated with a higher risk of several cancers, including renal cell carcinoma. In this case-control study, we examined the frequency of single nucleotide polymorphisms (rs182052G>A, rs266729C>G, and rs3774262G>A) in the adiponectin gene (ADIPOQ) in 1004 patients with clear cell renal cell carcinoma (ccRCC) compared with a group of healthy subjects (n = 1108). Fasting serum adiponectin concentrations were also ex  ...[more]

Similar Datasets

| S-EPMC5463157 | biostudies-literature
| S-DIXA-D-1153 | biostudies-other
| S-EPMC4941305 | biostudies-literature
| S-EPMC9493111 | biostudies-literature
| S-EPMC8799361 | biostudies-literature
| S-EPMC4332813 | biostudies-literature
| S-EPMC4928052 | biostudies-literature
| S-EPMC7068649 | biostudies-literature
| S-EPMC6676677 | biostudies-literature
| S-EPMC8740509 | biostudies-literature