Ontology highlight
ABSTRACT:
SUBMITTER: Uddin N
PROVIDER: S-EPMC4471798 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Uddin Nizam N Kim Rae-Kwon RK Yoo Ki-Chun KC Kim Young-Heon YH Cui Yan-Hong YH Kim In-Gyu IG Suh Yongjoon Y Lee Su-Jae SJ
Cancer science 20150508 6
Metastasis of breast cancer is promoted by epithelial-mesenchymal transition (EMT). Emerging evidence suggests that STAT3 is a critical signaling node in EMT and is constitutively activated in many carcinomas, including breast cancer. However, its signaling mechanisms underlying persistent activation of STAT3 associated with EMT remain obscure. Here, we report that PIM2 promotes activation of STAT3 through induction of cytokines. Activation of STAT3 caused an increase in PIM2 expression, implica ...[more]