Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease.
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ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC4471879 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease.
Yang Yue Y Keene C Dirk CD Peskind Elaine R ER Galasko Douglas R DR Hu Shu-Ching SC Cudaback Eiron E Wilson Angela M AM Li Ge G Yu Chang-En CE Montine Kathleen S KS Zhang Jing J Baird Geoffrey S GS Hyman Bradley T BT Montine Thomas J TJ
Journal of neuropathology and experimental neurology 20150701 7
Human cerebrospinal fluid (CSF) contains diverse lipid particles, including lipoproteins that are distinct from their plasma counterparts and contain apolipoprotein (apo) E isoforms, apoJ, and apoAI, and extracellular vesicles, which can be detected by annexin V binding. The aim of this study was to develop a method to quantify CSF particles and evaluate their relationship to aging and neurodegenerative diseases. We used a flow cytometric assay to detect annexin V-, apoE-, apoAI-, apoJ-, and amy ...[more]
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