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Impact of autoimmune risk alleles on the immune system.

ABSTRACT: Genetic analyses of autoimmune diseases have revealed hundreds of disease-associated DNA variants, but the identity and function of the causal variants are understudied and warrant deeper mechanistic studies. Here, we highlight methods for deciphering how alleles that are associated with autoimmune disease alter the human immune system, and suggest strategies for future autoimmune genetic research.

SUBMITTER: Ray JP 

PROVIDER: S-EPMC4471922 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Impact of autoimmune risk alleles on the immune system.

Ray John P JP   Hacohen Nir N  

Genome medicine 20150619 1

Genetic analyses of autoimmune diseases have revealed hundreds of disease-associated DNA variants, but the identity and function of the causal variants are understudied and warrant deeper mechanistic studies. Here, we highlight methods for deciphering how alleles that are associated with autoimmune disease alter the human immune system, and suggest strategies for future autoimmune genetic research. ...[more]

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