A 40-bp VNTR polymorphism in the 3'-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism.
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ABSTRACT:
SUBMITTER: Sery O
PROVIDER: S-EPMC4472402 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
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A 40-bp VNTR polymorphism in the 3'-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism.
Šerý Omar O Paclt Ivo I Drtílková Ivana I Theiner Pavel P Kopečková Marta M Zvolský Petr P Balcar Vladimir J VJ
Behavioral and brain functions : BBF 20150611
<h4>Background</h4>ADHD and alcoholism are psychiatric diseases with pathophysiology related to dopamine system. DAT1 belongs to the SLC6 family of transporters and is involved in the regulation of extracellular dopamine levels. A 40 bp variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region of DAT1/SLC6A3 gene was previously reported to be associated with various phenotypes involving disturbed regulation of dopaminergic neurotransmission.<h4>Methods</h4>A total of 1312 s ...[more]
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