An immunosuppressive antibody-drug conjugate.
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ABSTRACT:
SUBMITTER: Wang RE
PROVIDER: S-EPMC4472444 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
An immunosuppressive antibody-drug conjugate.
Wang Rongsheng E RE Liu Tao T Wang Ying Y Cao Yu Y Du Jintang J Luo Xiaozhou X Deshmukh Vishal V Kim Chan Hyuk CH Lawson Brian R BR Tremblay Matthew S MS Young Travis S TS Kazane Stephanie A SA Wang Feng F Schultz Peter G PG
Journal of the American Chemical Society 20150227 9
We have developed a novel antibody-drug conjugate (ADC) that can selectively deliver the Lck inhibitor dasatinib to human T lymphocytes. This ADC is based on a humanized antibody that selectively binds with high affinity to CXCR4, an antigen that is selectively expressed on hematopoietic cells. The resulting dasatinib-antibody conjugate suppresses T-cell-receptor (TCR)-mediated T-cell activation and cytokine expression with low nM EC50 and has minimal effects on cell viability. This ADC may lead ...[more]
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