Dataset Information

Cardiovascular risk factors and cognitive decline in older people with type 2 diabetes.

ABSTRACT:

Aims/hypothesis

The aim of this work was to assess the role of well-established cardiovascular risk factors in the late-life cognitive decline of patients with type 2 diabetes.

Methods

Data from 831 participants (aged 60-75 years) attending the 4 year follow-up of the Edinburgh Type 2 Diabetes Study (ET2DS) were used. Smoking history (pack-years), BP, HbA1c, plasma glucose and cholesterol were determined at baseline clinics (single time measurements) and/or from serial data recorded on a clinical management database from diagnosis until recruitment ('historical' data). Principal component analysis derived a factor, g, of general ability from seven cognitive tests. Linear regression models of follow-up g were adjusted for baseline g to represent 4 year cognitive change. 'Accelerated late-life cognitive decline' was defined as scoring in the lowest tertile of '4 year cognitive change' regression scores. Analyses controlled for age and sex.

Results

A baseline history of moderate/heavy smoking (? 10 pack-years) and a 1% increased historical HbA1c (equivalent to an increase by 11 mmol/mol) predicted a 64% (OR 1.64; 95% CI 1.14, 2.34; p = 0.007) and 21% (OR 1.21; 95% CI 1.00, 1.45; p = 0.046) increased risk of accelerated cognitive decline, respectively. When treated as continuous measures, higher pack-years, historical HbA1c and historical BP emerged as significant independent predictors of 4 year decline in g (standardised ? range -0.07 to -0.14; all p ? 0.05).

Conclusions/interpretation

Increased smoking and poorer glycaemic control (with relatively weaker findings for BP) during the life-course were independently associated with accelerated late-life cognitive decline. Where possible, evaluation is warranted of these risk factors as targets for intervention to reduce the burden of cognitive impairment in diabetes.

SUBMITTER: Feinkohl I

PROVIDER: S-EPMC4473016 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Publications

Cardiovascular risk factors and cognitive decline in older people with type 2 diabetes.

Feinkohl Insa I Keller Markéta M Robertson Christine M CM Morling Joanne R JR McLachlan Stela S Frier Brian M BM Deary Ian J IJ Strachan Mark W J MW Price Jackie F JF

Diabetologia 20150407 7

<h4>Aims/hypothesis</h4>The aim of this work was to assess the role of well-established cardiovascular risk factors in the late-life cognitive decline of patients with type 2 diabetes.<h4>Methods</h4>Data from 831 participants (aged 60-75 years) attending the 4 year follow-up of the Edinburgh Type 2 Diabetes Study (ET2DS) were used. Smoking history (pack-years), BP, HbA1c, plasma glucose and cholesterol were determined at baseline clinics (single time measurements) and/or from serial data record ...[more]

PMID: 25847351

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Dataset Information

Cardiovascular risk factors and cognitive decline in older people with type 2 diabetes.

Aims/hypothesis

Methods

Results

Conclusions/interpretation

Publications

Cardiovascular risk factors and cognitive decline in older people with type 2 diabetes.

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