Ontology highlight
ABSTRACT:
SUBMITTER: Sharan S
PROVIDER: S-EPMC4474166 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
CPT: pharmacometrics & systems pharmacology 20141008
Circulating angiogenic factors (CAF) like vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and sVEGFR2 have potential as biomarkers for antiangiogenic therapy. The interpretation of changes in CAF is complicated by the dynamic nature of the tumor and host cells emanating CAF in response to VEGF pathway inhibition. We developed a systems pharmacology model of anti-VEGF agents to investigate CAF modulation by tumor and host cells, and the relationship between overall CAF ...[more]