Us9-Independent Axonal Sorting and Transport of the Pseudorabies Virus Glycoprotein gM.

ABSTRACT: Axonal sorting and transport of fully assembled pseudorabies virus (PRV) virions is dependent on the viral protein Us9. Here we identify a Us9-independent mechanism for axonal localization of viral glycoprotein M (gM). We detected gM-mCherry assemblies transporting in the anterograde direction in axons. Furthermore, unlabeled gM, but not glycoprotein B, was detected by Western blotting in isolated axons during Us9-null PRV infection. These results suggest that gM differs from other viral proteins regarding axonal transport properties.

SUBMITTER: Kratchmarov R 

PROVIDER: S-EPMC4474295 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature