Ontology highlight
ABSTRACT:
SUBMITTER: Yasamut U
PROVIDER: S-EPMC4474434 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yasamut Umpa U Tongmuang Nopprarat N Yenchitsomanus Pa-thai PT Junking Mutita M Noisakran Sansanee S Puttikhunt Chunya C Chu Justin Jang Hann JJ Limjindaporn Thawornchai T
PloS one 20150619 6
Rearrangement of membrane structure induced by dengue virus (DENV) is essential for replication, and requires host cellular machinery. Adaptor protein complex (AP)-1 is a host component, which can be recruited to components required for membrane rearrangement. Therefore, dysfunction of AP-1 may affect membrane organization, thereby decreasing replication of virus in infected cells. In the present study, AP-1-dependent traffic inhibitor inhibited DENV protein expression and virion production. We ...[more]