Ontology highlight
ABSTRACT:
SUBMITTER: Bartok O
PROVIDER: S-EPMC4474529 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Bartok Osnat O Teesalu Mari M Ashwall-Fluss Reut R Pandey Varun V Hanan Mor M Rovenko Bohdana M BM Poukkula Minna M Havula Essi E Moussaieff Arieh A Vodala Sadanand S Nahmias Yaakov Y Kadener Sebastian S Hietakangas Ville V
The EMBO journal 20150427 11
Nutrient sensing pathways adjust metabolism and physiological functions in response to food intake. For example, sugar feeding promotes lipogenesis by activating glycolytic and lipogenic genes through the Mondo/ChREBP-Mlx transcription factor complex. Concomitantly, other metabolic routes are inhibited, but the mechanisms of transcriptional repression upon sugar sensing have remained elusive. Here, we characterize cabut (cbt), a transcription factor responsible for the repressive branch of the s ...[more]