Ontology highlight
ABSTRACT:
SUBMITTER: Yukl S
PROVIDER: S-EPMC4474533 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Yukl Steven S Pillai Satish S Li Peilin P Chang Karen K Pasutti William W Ahlgren Chris C Havlir Diane D Strain Matthew M Günthard Huldrych H Richman Douglas D Rice Andrew P AP Daar Eric E Little Susan S Wong Joseph K JK
Virology 20090305 1
The ability of HIV to establish latent infection in CD4+ lymphocytes represents a major barrier to the eradication of HIV. It is not clear what mechanisms favor latent over productive infection, but prior studies have suggested a role for the viral transcription factor Tat or its RNA target, TAR. Using samples from five individuals who were started on ART within 6 months of infection and achieved a viral load <50 (suppressed), we isolated one- and two-exon tat RNA from HIV propagated ex vivo fro ...[more]