Ontology highlight
ABSTRACT:
SUBMITTER: Cussiol JR
PROVIDER: S-EPMC4475403 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
The EMBO journal 20150420 12
In response to DNA damage, checkpoint signalling protects genome integrity at the cost of repressing cell cycle progression and DNA replication. Mechanisms for checkpoint down-regulation are therefore necessary for proper cellular proliferation. We recently uncovered a phosphatase-independent mechanism for dampening checkpoint signalling, where the checkpoint adaptor Rad9 is counteracted by the repair scaffolds Slx4-Rtt107. Here, we establish the molecular requirements for this new mode of check ...[more]