Ontology highlight
ABSTRACT:
SUBMITTER: McMaster SR
PROVIDER: S-EPMC4475417 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
McMaster Sean R SR Wilson Jarad J JJ Wang Hong H Kohlmeier Jacob E JE
Journal of immunology (Baltimore, Md. : 1950) 20150529 1
CD8 airway resident memory T (TRM) cells are a distinctive TRM population with a high turnover rate and a unique phenotype influenced by their localization within the airways. Their role in mediating protective immunity to respiratory pathogens, although suggested by many studies, has not been directly proven. This study provides definitive evidence that airway CD8 TRM cells are sufficient to mediate protection against respiratory virus challenge. Despite being poorly cytolytic in vivo and faili ...[more]